Helping The others Realize The Advantages Of ceesdekker.net
Helping The others Realize The Advantages Of ceesdekker.net
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Halfway as a result of his occupation, Cees Dekker reinvented himself. After several years of hardcore physics, he shifted his focus to ‘nanobiology’ with the flip with the millennium. A term he coined himself, being a matter of simple fact.
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‘It absolutely was only a issue of choosing up a book on mobile biology and starting to study. I'd come from a globe of extremely-substantial vacuums, cryostats and quantum phenomena, and now I was working at place temperature with molecular biology kits.
Non-equilibrium folding of specific DNA molecules recaptured approximately one thousand moments in the good point out nanopore
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Electrical transport in monolayers of phthalocyanine molecular wires and AFM imaging of one wire bridging two electrodes
What distinguishes biology from chemistry is always that these components jointly make up a residing procedure. The secret of reported existence, I do think, lies inside the interactions, the interaction of These molecules. The massive query with regard to the origin of existence remains unanswered. How did we ever evolve from basic molecules into the really elaborate techniques we see currently? We have no idea. I would like to operate on These types of massive, open up questions.’
2011, first in vitro measurements of transport throughout one biomimetic nuclear pore advanced; progress of multiplexed magnetic tweezers for kilo-molecule experiments; and solved the mechanism of homology recognition in DNA homologous recombination
The rotors harness Vitality from a nanoscale drinking water and ion movement that is created by a static chemical or electrochemical likely gradient within the nanopore, which are founded by way of a salt gradient or applied voltage, respectively. These artificial nanoengines self-Manage and function autonomously in physiological conditions, suggesting solutions to constructing Electrical power-transducing motors at nanoscale interfaces.
Bulk-surface area coupling identifies the mechanistic link ceesdekker concerning Min-protein patterns in vivo and in vitro
Testing pseudotopological and nontopological types for SMC-pushed DNA loop extrusion towards roadblock-traversal experiments
Quite a few new phenomena have been discovered, and he and his exploration group founded a leading position With this area of investigate. Dekker and his investigation group uncovered new physics of nanotubes in addition to explored the feasibility of molecular electronics. In 1998, they were the primary to construct a transistor based upon just one nanotube molecule.
As an example, we look at the nucleopore elaborate, a gateway involving the cell nucleus and also the cytoplasm. This is a really intricate technique and thus difficult to review within a cell, so we use biomimetics. We reconstruct holes after which you can insert specific components of the nucleopore advanced to study transport by it at The only-molecule amount.’
Dekker heeft fundamentele ontdekkingen gedaan op het gebied van koolstof nanobuisjes. Mede vanwege deze werkzaamheden is hij al jaren de meest geciteerde fysicus in Nederland. Tegenwoordig onderzoekt hij met enkel-molecuultechnieken de biofysica van moleculen in de biologische cel. Dekker is naast zijn wetenschappelijk werk ook bekend vanwege zijn belangstelling voor de relatie tussen geloof en wetenschap en de discussie rond smart design in 2005. (nl)